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    Try out PMC Labs and tell us what you think. Learn More. Consequently, in many centers nutritional therapy is now considered first line therapy in the induction of remission of active CD. However, the use of nutritional therapy in complicated CD has yet to be fully determined.
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    Crohn's disease

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    Volume 27 Issue Supplement_1 | Inflammatory Bowel Diseases | Oxford Academic

    In modern medicine, the oral cavity has often been viewed as a passive conduit to the upper airways and gastrointestinal tract; however, its connection to the rest of the body has been increasingly explored over the last 40 years. For several diseases, the periodontium and gingiva are at the center of this oral-systemic link. Classically, the etiology of gingival inflammation gingivitis is oral microbial dysbiosis in the subgingival crevice that can lead to destructive periodontal disease periodontitis ; however, the current understanding of gingival involvement in IBD is that it may represent a separate disease entity from classical gingivitis, arising from mechanisms related to systemic inflammatory activation of niche-resident immune cells. Synthesizing available evidence, we hypothesize that once established, IBD can be driven by microbiomial and inflammatory changes originating specifically from the gingival niche through saliva, thereby worsening IBD outcomes and thus perpetuating a vicious cycle. To support and explore this gum—gut axis, we 1 provide a narrative review of historical studies reporting gingival and periodontal manifestations in IBD, 2 describe the current understanding and advances for the gum—gut axis, and 3 underscore the importance of collaborative treatment and research plans between oral and GI practitioners to benefit this patient population. The oral cavity serves as the entry point to the gastrointestinal tract and is also continuous with the nasal cavity and the skin of the face 1.
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    Impaired neurocognitive and psychomotor performance in patients with inflammatory bowel disease

    Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.
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    Crohn's disease is a type of inflammatory bowel disease IBD that may affect any segment of the gastrointestinal tract from the mouth to the anus. Other complications outside the gastrointestinal tract may include anemia , skin rashes , arthritis , inflammation of the eye , and fatigue. While the precise causes of Crohn's disease are unknown, it is believed to be caused by a combination of environmental, immune , and bacterial factors in genetically susceptible individuals. About half of the overall risk is related to genetics, with more than 70 genes having been found to be involved.
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