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Penetration enhancer and nail

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Comments(3)

Tejin wrote 42 days ago:

Do I hear Cradle of Filth at the beginning?

Mushakar wrote 83 days ago:

you have to be perverted, nasty and treat her like shit to get her attention.

Vubar wrote 30 days ago:

Been waiting for a nappi comp!!!

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Try out PMC Labs and tell us what you think. Learn More. Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of penetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail pathologies. In this work, different chemical substances have been evaluated as potential penetration enhancers.

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Recent Patents on Permeation Enhancers for Drug Delivery Through Nails

Novel nail penetration enhancer containing vesicles "nPEVs" for treatment of onychomycosis

DOI : The human nail is a unique barrier with a keratinized constitution that favors protection and fine touch. However, many disorders can affect the nail, among them, are the onychomycosis and psoriasis. Systemic oral therapy has been applied to treat these diseases, even presenting disadvantages, including side effects, drug interactions, contraindications, toxicity, high cost and low patient compliance. A great option to succeed in dealing with the problems associated with oral therapy is the topical administration of drugs.

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Novel nail penetration enhancer containing vesicles "nPEVs" for treatment of onychomycosis

E Cutrin Gomez, S. N2 - Nail delivery has interest for local treatment of nail diseases. In this work, different chemical substances have been evaluated as potential penetrationenhancers.

Onychomycosis is considered a stubborn nail fungal infection that does not respond to conventional topical antifungal treatments. Three nPEs N-acetyl-L-cysteine, thioglycolic acid, and thiourea were used. They were selected for their optimum particle size of The in vitro microbiological screening of the antifungal activity of these two formulae showed significantly larger zones of inhibition in comparison with the marketed product.